9pm, Ugly Betty, E4
Claire Meade’s up in court for Fay’s murder, with guest star Barry Bostwick as her defence lawyer and ER’s Rocket Romano on the side of the prosecution - but it looks like Betty may save the day after a scoosh of Claire’s favourite perfume sends her round the twist, chucking bins through windows and indulging in extreme public displays of affection with Henry… just in time to prove the perfume’s been poisoned. Meanwhile it looks like Christina may yet give in to Wili’s mad surrogacy plan.

10pm, Samantha Who?, E4
NEW SERIES This is one of our ones to watch this autumn. Married With Children’s Christina Applegate heads the sitcom cast as a woman who wakes from a coma with amnesia and is horrified to find out she used to be mean, vowing to change her ways and make up for all the trouble she has caused in the past. We’ve got the full lowdown and a round-up clip here (though you might want to avoid the clip if you don’t want to know too much in advance…)

10pm, Grey’s Anatomy, Living
NEW SERIES After last season, with Meredith almost dying after the ferry accident, and Cristina being jilted at the altar, you might wonder how on earth the makers can up the ante. Well, they can! Meredith’s less than impressed that her extremely pretty half-sister Lexie is now an intern at the hospital, and if that wasn’t bad enough it seems she may have some competition for McDreamy’s affections in the shape of nurse Rose. Bailey’s also in the mood for a fight, having lost out on the chief resident post to Callie, and the George/Izzy fiasco rumbles on.